Seeing as they all suffer in different ways you can't really say that one is worse off then the other.
Kyo - Mother killed herself, is gonna be locked up
+ Tohru loves him, Kazuma is kind to him and accepts him
Yuki - His mother gave him to Akito to get a better family status, he was mentally damaged thanks to Akito.
+ he found the courage to escape, Tohru is his friend as well as many others, he's in love with Machi, he's getting on better with his brother.
Momiji - his mother wanted nothing to do with him, he can't play the violin any more because of Momo, Akito hates him.
+ Momo wants him to be her brother, his father loves him, he has a crush on Tohru.
Shigure - hmm nothing really
+ He's in love with Akito (also counted as a bad thing if you want it to be), he slept with Ren Akito's mother, he has two great friends.
Hatori - He's blind in his left eye thanks to Akito, he lost his girlfriend/second cousin Kana because of Akito.
+ He gets together with Mayu-chan in the end, he's finally begining to get a little happier.
Ayame - He regrets what he did to his brother, he feels alone in the world.
+ His brother is finally starting to like him. He's been dating Mine for a while now secrectly.
Kagura - She only played with Kyo because it made her feel better and forced herself to love him at first after convincing him to take his beads off then running away, She'll never be with Kyo.
+ She has a loving mother, for sme reason she's refused to give up on Kyo after crying alone for days.
Haru - Rin broke up with him, he was teased for being the cow when he was younger, he has a split personality.
+ Rin still loves him, he's one of the few Akito hasn't hurt yet.
Kisa - She was beaten by Akito and took two weeks to fully heal, she's been bullied in school because of her appearance.
+ Tohru is like a sister to her, her mother loves her, Hiro loves her, the bullying has stopped.
Hiro - He saw Rin get pushed out the window, it was kinda his fault Kisa started to get picked on, he feels weak and childish.
+ He's finally growing up, he's in love with Kisa who loves him too.
Rin - She was pushed out a window by Akito, she was lied to by Ren who only used her, she was locked up by Akito in the neko room, her parents didn't want her anymore after she asked why they were so happy and all the other zodiac and their parents weren't.
+ Haru loves her and she's slept with him, Tohru is taking care of her, she's gotten back together with Haru.
Kureno - Akito found out he was released by the curse and began screaming at him, he's promised to always stay by Akito's side and to look after her, he's not allowed to see the other zodiacs appart from new years when he doesn't get to talk to them much, he's not allowed to leave the estate too often, he can't see Arisa again because of his promise to Akito, he's slept with Akito so she could make Shigure jealous.
+ He can hug normal people, he's in love with Arisa.
Akito - She's dying/ very sick, her mother decided to raise her as a man, her mother would prefer to be dead with Akira than with Akito, she's mentally unstable because of finding out Kureno isn't cursed, she doesn't have a bond with the zodiacs as the other gods did.
+ She's in love with Shigure, she's slept with him, he's one of the few people who're kind to her, she did have kind of a happy childhood.
If you think about it really Kureno is the one with the worst life.