X-Yami-no-Ko-X
So the discussion. Have you ever seen or heard about a human-deity relationship going sour? What did they do? What do you think someone should do if it does happen? Why do you think it happens?
It happens. It's not much different in my mind than any other sort of relationship going south - I think of the Gods much as I'd think of any other individual. Personalities can clash, people change over time, we end up in different circumstances, slights or insults happen - all those things can compromise a relationship into coming apart.
One of the harder lessons of adult life is that friendships can be, and often are, transient. Not everyone we meet or associate with is a friend for life. Deities and spirits are no different. We pass like trains in the night.
Sometimes you can repair the damage done. Other times you simply have to move on and learn to live with it.