What kind of programs are you running under wine that requires it to be root? Most of the time you start a program under wine using ether:
$ wine "name of program"
or
$ wine /path/to/exuctable
Two things that come to mind right off the bat did you set up the sound under wine? Usually it is a good idea to configure wine right after install, this is done via the winecfg command:
$ winecfg
For referance here is a screenshot showing my Audio tab under winecfg
http://imgur.com/wKfOh.pngAlso make sure that you have the most current version of wine installed, looking at
wineHQ the latest development build is 1.3.2. As a general note about wine though it is always a good idea to check the
AppDB for any program you are trying to use with wine, it is usually good about informing how well that program works under wine and if there are any needed hacks or tricks to get it to work.
I hope this helps any at all
PS. This topic has been moved to Tech Support because this is where it belongs