A sprawling metropolis in the Kanto region. It lies in between Celadon City, Vermilion City, Lavender Town, and Cerulean City. It is home to Sabrina, the Saffron City Gym Leader.

Saffron City is one of the busiest and largest cities in the region, and is even famous outside of Kanto. The large Silph Co. headquarters building stands firm as the city's centerpiece, while two gyms dominate the north-eastern corner district. Not only is this the central business district of Kanto, it also holds the region's largest infrastructure, including the Magnet Train station, which allows ease of access between Johto and Kanto.