a metropolis located in western Hoenn. It is one of the largest cities in the region. The first gym is located here with Roxanne as the Gym Leader.

Rustboro serves as the establishment for the Devon Corporation, a company which makes many items for Pokémon Trainers. The company headquarters is located in the northwest corner of the city, and takes the appearance of a very olden-style building. Apart from developing improved and innovative items, the company also revives Pokémon from fossils. The Devon Corporation are also attempting to build impossible machines such as one that can transform people into Pokémon. In the south section of the town is an apartment complex for Devon employees.